Psalms 69:20
Reproach hath broken my heart; and I am full of heaviness: and I looked for some to take pity, but there was none; and for comforters, but I found none. Reproach hath broken my heart; and I am full of heaviness: and I looked for some to take pity, but there was none; and for comforters, but I found none.
Christ Himself spoke these words centuries before the crucifixion as prophecy of the treatment and suffering He would receive in order to fulfill God's purpose. That prophecy was fulfilled in His sufferings upon the cross, where He suffered alone without human sympathy. It was fulfilled also in Gethsemane in the trial of the Saviour, where He longed for human sympathy while bearing the load of the world's sin as a transgressor and feeling the Father withdraw light and presence from Him.
A second time He rose and came to His disciples hoping for pity and comfort, but found them sleeping in stupor. They were unable to speak a word of comfort or pity when they saw His pale face stained with bloody sweat and marked with grief. Reproach broke His heart and filled Him with heaviness, weighing Him down with sorrow. He looked for some to take pity and for comforters, but found none, with no one to pity or comfort Him in His loneliness and anguish.
His heart was broken by the anguish of bearing sin as humanity's substitute. The bitterness came from the sense of sin bringing the Father's wrath upon Him, not merely from physical suffering. As the substitute for sinful humanity He suffered under divine justice, facing what it means for sinners to stand before God without an intercessor. In His thirst He was given gall for food and vinegar to drink.